Physiological roles of Runx3 in female reproductive organs in mice

Runx3(Runtdomaintranscriptionfactor3)はRunxファミリーに属する転写因子で雌マウスにおいてRunx3 mRNAは, 卵巣や子宮に発現していた。雌のRunx3(-/-)マウスは不妊であった。Runx3(-/-)マウスは卵胞形成異常を起こしており, 無排卵であった。一方で, 排卵能および黄体形成能は有していた。以上より, Runx3は卵胞形成および排卵制御に関与していることを明らかにした。Runx3(-/-)マウスの子宮は萎縮している。子宮内膜上皮細胞では, E2依存性の細胞増殖が起こらなかった。しかし,子宮内膜間質細胞では, E2, P4存在下で正常に細胞増殖が起きた。以上より, Runx3はE2による子宮の細胞増殖に関与していることを明らかにした

Risk Management for Gastrointestinal Endoscopy in Elderly Patients: Questionnaire for Patients Undergoing Gastrointestinal Endoscopy

More elderly patients now undergo gastrointestinal endoscopy following recent advances in endoscopic techniques. In this study, we conducted a high-risk survey of endoscopies in Japan, using a questionnaire administered prior to upper gastrointestinal tract endoscopy (UGITE), and identified anticholinergic agents and glucagon preparations as high-risk premedication. We also evaluated the cardiovascular effects of anticholinergic agents and glucagon through measurements of plasma levels of human atrial natriuretic peptide (hANP) and human brain natriuretic peptide (hBNP). The subjects were 1480 patients who underwent UGITE. Nurses administered a pre-endoscopy questionnaire, questioning subjects regarding heart disease, hypertension, glaucoma, and urinary difficulties as risk factors for anticholinergic agents, and Diabetes mellitus as a risk factor for glucagon preparations. Evaluation of subjects divided into under 65 and over 65 age groups revealed that in subjects aged 65 and over, risk factors for anticholinergic agents were significantly more high than those for glucagon. Analysis of the cardiovascular effects of anticholinergic agents and glucagon, in the elderly patients showed that hANP levels were significantly higher following administration of anticholinergic agents, but the change was not significant for glucagon premedication. Taking a detailed history before UGITE with the aid of a questionnaire at the same time as informed consent is obtained, is extremely useful in terms of risk management and selection of the appropriate premedication

A Preliminary Study on Education for Disaster Risk Reduction in Thailand

This paper reports preliminary findings from the fieldwork conducted in June and September 2022 on disaster education initiatives in Thailand. Firstly, we think that in-service teacher education can off er an effective means of disseminating disaster education in Thailand. Secondly, we found that disaster risk reduction education is mostly taught in social studies at school and that evacuation drills are conducted as extracurricular activities with the support of experts. It also became clear that, unlike schools in Japan, schoolteachers and schools in Thailand do not have a specific role to play in the event of a disaster. In other words, children are considered to be part of the local community and hence, to be rescued by the local authorities. Nevertheless, the role of education in fostering disaster awareness is significant, and we hope to contribute the development of content for disaster education and in-service teacher education for the pre-school and early primary school years.本研究は，JSPS 科研費JP21KK0037の助成を受けたものです

The Production of Safety School Space from Climate Disasters in Doi Mae Salong Forest, Upland Northern Thailand

This research is conducted in Santikhiri, a hilltop village on the highest peak in the Doi Mae Salong forest, where climate change increases the intensity and frequency of natural disasters that immensely affect the local children in the mountainous area in Chiang Rai province, northern Thailand. There is only one secondary-level school in this forest landscape educating around 900 schoolchildren from various minority hill-tribe ethnic groups. This paper examines everyday life experiences recentering the village school's role as the producer of safe space for the forest children from climate disasters. School safety is a global framework for recognizing the importance of child-centered efforts in building disaster resilience for the education sector. Parameters and variables used to measure the disaster resilience of schools are adapted from the Climate Resilience Model and School Safety Model by Tong et al. (2012), covering three dimensions: 1) institutional issues, 2) physical conditions, and 3) external relationships. Lefebvre's Spatial Triad Framework is applied to dialectically interconnect dimensions to produce a safe space at the village school to protect the students from climate disaster threats. A mix-method method is applied with several techniques to collect data, including participant observation, semi-structured interviews, and content analysis. Furthermore, a scale Likert survey examined statements on school safety from educational practitioners in the rural forest area. The research argues that the production of safe space at the school is intertwined with budget allocation for disaster preparedness and response (institutional issue as l'espace concu), environmental protection campaign to create a hygienic school environment (physical conditions as l'espace percu), and support from the local community (external relations as l'espace vecu). However, the school is also two contradicting spaces of conceived and lived. Through the critical examination of the production of safe space, the school is a planned space of hierarchical power relations in institutional issues focusing on impacts from rapid-onset disasters. Concurrently, the forest children are still marginalized from external relationships and natural conditions' slow-onset climate change impacts

セイギョ ショウテン ノ チガイ ニヨル ダイエット コウドウ ノ イシ ケッテイ

修士論文概要(Summary of Master\u27s Theses

防災・減災につなげるまち歩き

日本は地震災害・津波災害・土砂災害・洪水災害・火山災害・雪害・突風災害など，自然災害が発生する要因を多く抱えており，毎年人的・物的被害が発生している。このような国に居住するにあたり，防災教育は不可欠な教育項目である。自らの身を守る能力を養い、自律的な災害行動を促すためにできるだけ効果的な防災教育を設計していくことが課題となる。本稿では, 参加型都市計画の一手法を応用し, 地理と風景の中に残る災害の痕跡を手掛かりに日常の環境を詳細に観察し体験するまち歩きの教育アプローチについて説明し、 2012年の九州北部豪雨災害を題材とした小学生の防災教育の一環としてのまち歩きの事例を報告する。Japan is permanently subjected to disasters such as earthquakes, tsunamis, landslides, floods, volcanic eruptions, and typhoons which cause many casualties and a great deal of damage to property each year. Education for risk prevention is an indispensable part of the curriculum of primary and secondary schools. But wouldn't the first challenge for such a curriculum be to include concrete guidelines in the event of a disaster? This article gives an account of an educational approach focused on the experience and careful observation of the everyday environment using geography and the traces of past events in the landscape: the machi aruki まち歩き technique inspired by participative urban planning. The article presents an experiment carried out in the primary school of the district of Uchinomaki in the city of Aso in Kumamoto County which was subjected to violent floods following heavy rainfall in Kyūshū in 2012

Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole

Non-steroidal anti-inflammatory drugs (NSAIDs), which are used for the treatment of several inflammatory disorders including rheumatoid arthritis, are well known to cause gastroduodenal mucosal lesions as an adverse effect. Recently, the serious problem of NSAID-induced small intestinal damage has become a topic of great interest to gastroenterologists, since capsule endoscopy and double-balloon enteroscopy are available for the detection of small intestinal lesions. Such lesions have been of great concern in clinical settings, and their treatment and prevention must be devised as soon as possible. Proton pump inhibitors (PPI), such as lansoprazole and omeprazole, show a potent anti-secretory effect. PPIs also have a gastroprotective effect, independent of their anti-secretory actions, which is probably mediated by inhibition of neutrophil functions as well as antioxidant actions. Administration of lansoprazole reduced the severity of the intestinal lesions in a dose-dependent manner, but omeprazole had no effect. The amount of heme oxygenase-1 (HO-1) protein in the intestinal mucosa was significantly increased by lansoprazole, but not by omeprazole. These results suggest that lansoprazole, but not omeprazole, ameliorates indomethacin-induced small intestinal ulceration through upregulation of HO-1/carbon monoxide. Therefore, lansoprazole may be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine